Androgen insensitivity syndrome (AIS) is caused by a genetic alteration that means the body cannot respond to testosterone either completely or partially. Testosterone is the sex hormone produced by the testicles.
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Whats androgen insensitivity syndrome? – Most popular questions
What happens to someone who is born with androgen insensitivity?Babies born with partial androgen insensitivity syndrome may have sexual characteristics that are typical of a male, a female, or both. They may have a partial closing of the outer vagina, an enlarged clitoris and a short vagina. They may be raised as males or as females and have a male or female gender identity.
What is androgen insensitivity caused by?Causes. AIS is caused by genetic defects on the X chromosome. These defects make the body unable to respond to the hormones that produce a male appearance
Do people with androgen insensitivity have vaginas?Complete androgen insensitivity syndrome (CAIS) CAIS is not usually obvious from birth because affected babies have female genitals, including a vagina and labia (folds of skin either side of the vaginal opening).
What are the symptoms of androgen insensitivity syndrome?What are the symptoms of androgen insensitivity syndrome?
- Abnormally tall stature for a female during puberty.
- Amenorrhea (no menstrual periods).
- Little or no pubic hair or underarm hair during puberty.
- Narrow or shallow vagina.
- Undescended testicles (testicles that are still in your abdominal cavity).
What do people with AIS look like?A person with complete AIS appears to be female but has no uterus. They have very little armpit and pubic hair. At puberty, female sex characteristics (such as breasts) develop. However, the person does not menstruate and become fertile.
Can a man with AIS have a baby?There are specialist healthcare psychologists who can help people with AIS understand their bodies and sex development. The sex development of people with AIS means they will not be able to become pregnant or make their partner pregnant.
Is AIS the same as intersex?AIS is just one of a number of medical diagnoses (or intersex variations) that affect the development of the reproductive and genital organs.
What celebrity has androgen insensitivity?Hanne Gaby Odiele
She has androgen insensitivity syndrome (AIS) which means she has male chromosomes but her body has not responded properly to testerone so the penis was not formed.
Do intersex people have periods?Mostly, it depends on the sexual and reproductive organs an individual is born with, whether they will have periods or not. If an intersex person is born with a functioning uterus, ovaries, and a vagina, most likely that person will start menstruating at puberty.
Can a person be born with both male and female parts?Ambiguous genitalia is a rare condition in which an infant’s external genitals don’t appear to be clearly either male or female. In a baby with ambiguous genitalia, the genitals may be incompletely developed or the baby may have characteristics of both sexes.
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Androgen Insensitivity Syndrome
- Summary: Androgen Insensitivity SyndromeAndrogen insensitivity syndrome is a genetic condition which affects a child’s sexual development before birth and during puberty. People with this syndrome are genetically male (they carry both an X and a Y chromosome), but are born with all or some of the physical traits of a female. This happens because a mutation on the X chromosome causes the body to resist androgen, the hormones that…
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- Source: https://www.chop.edu/conditions-diseases/androgen-insensitivity-syndrome
Androgen insensitivity syndrome – NHS
- Summary: Androgen insensitivity syndrome Androgen insensitivity syndrome (AIS) affects the development of a person’s genitals and reproductive organs.The 2 types of AIS are called complete androgen insensitivity syndrome (CAIS) and partial androgen insensitivity syndrome (PAIS).The genitals of a person with CAIS appear female.The genitals of a person with PAIS may appear as female or male. Sometimes PAIS is discovered because a baby’s genitals are not as expected for a…
- Rating: 1.2 ⭐
- Source: https://www.nhs.uk/conditions/androgen-insensitivity-syndrome/
Androgen Insensitivity Syndrome: Complete & Partial
- Summary: Androgen Insensitivity Syndrome: Complete & Partial Overview What is androgen insensitivity syndrome? Androgen insensitivity syndrome (AIS) occurs when someone is genetically male but is insensitive to androgens (male sex hormones). This means the person has male sex chromosomes (one X and one Y chromosome) but may have female genitals. AIS is a disorder of sex differentiation. It was previously called testicular feminization syndrome. It affects male fetuses as they develop…
- Rating: 2.78 ⭐
- Source: https://my.clevelandclinic.org/health/diseases/22199-androgen-insensitivity-syndrome
Androgen insensitivity syndrome Information – Mount Sinai
- Summary: Androgen insensitivity syndrome Testicular feminization Androgen insensitivity syndrome (AIS) is when a person who is genetically male (who has one X and one Y chromosome) is resistant to male hormones (called androgens). As a result, the person has some of the physical traits of a woman, but the genetic makeup of a man. The male reproductive structures include the penis, the…
- Rating: 1.37 ⭐
- Source: https://www.mountsinai.org/health-library/diseases-conditions/androgen-insensitivity-syndrome
Health Library Androgen Insensitivity Syndrome (AIS)
- Summary: Androgen Insensitivity Syndrome (AIS)Androgen Insensitivity Syndrome (AIS) is a condition that affects how the body grows and develops before birth and at puberty. People who have AIS make hormones called “androgens”. Testosterone is one type of androgen. People with AIS’ bodies do not respond to androgens. Their bodies develop on a less typical path. What Makes a Person’s Body Develop on a Male or Female Path? There are…
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- Source: https://www.cincinnatichildrens.org/health/a/androgen-insensitivity-syndrome
Androgen insensitivity syndrome – Wikipedia
- Summary: Androgen insensitivity syndromeAndrogen insensitivity syndromeAIS results when the function of the androgen receptor (AR) is impaired. The AR protein (pictured) mediates the effects of androgens in the human body.SpecialtyEndocrinology Androgen insensitivity syndrome (AIS) is a difference in sex development involving hormonal resistance due to androgen receptor dysfunction. It affects 1 in 20,000 to 64,000 XY (karyotypically male) births. The condition results in the partial…
- Rating: 3.59 ⭐
- Source: https://en.wikipedia.org/wiki/Androgen_insensitivity_syndrome
Androgen insensitivity syndrome – The Lancet
- Summary: Androgen insensitivity syndromeSummaryAndrogen insensitivity syndrome in its complete form is a disorder of hormone resistance characterised by a female phenotype in an individual with an XY karyotype and testes producing age-appropriate normal concentrations of androgens. Pathogenesis is the result of mutations in the X-linked androgen receptor gene, which encodes for the ligand-activated androgen receptor—a transcription factor and member of the nuclear receptor superfamily. This Seminar describes the clinical manifestations…
- Rating: 4.63 ⭐
- Source: https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(12)60071-3/fulltext
Androgen Insensitivity Syndrome – Medscape Reference
- Summary: Androgen Insensitivity Syndrome: Practice Essentials, Pathophysiology, Epidemiology Practice Essentials Androgen insensitivity syndrome (AIS), formerly known as testicular feminization, is an X-linked recessive condition resulting in a failure of normal masculinization of the external genitalia in chromosomally male individuals. This failure of virilization can be either complete androgen insensitivity syndrome (CAIS) or partial androgen insensitivity syndrome (PAIS), depending on the amount of residual receptor function.  Both individuals with partial androgen…
- Rating: 4.9 ⭐
- Source: https://emedicine.medscape.com/article/924996-overview
The Symptoms, Causes, and Treatment of Androgen Insensitivity
- Summary: How to Cope With Androgen Insensitivity Androgen insensitivity is an umbrella term for a number of genetic conditions where the body does not respond appropriately to testosterone and other androgens. There are multiple causes of androgen insensitivity syndromes (AIS). However, these conditions can broadly be divided into partial androgen insensitivity syndromes (PAIS) and complete androgen insensitivity syndromes (CAIS). With partial androgen insensitivity, the body has limited sensitivity to…
- Rating: 1.1 ⭐
- Source: https://www.verywellhealth.com/androgen-insensitivity-4173975